Hydrolase
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In biochemistry, a hydrolase is an enzyme that catalyzes the hydrolysis of a chemical bond. For example, an enzyme that catalyzed this reaction would be a hyrdrolase:
- A–B + H2O → A–OH + B–H
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Nomenclature
Systematic names of hydrolases are formed as "substrate hydrolase." However, common names are common, using only "substratease." For example, a nuclease is a hydrolase that cleaves nucleic acids.
Classification
Hydrolases are classified as EC 3 in the EC number classification of enzymes. Hydrolases can be further classified into four subclasses:
- EC 3.1 includes hydrolases that act on ester bonds
- EC 3.2 includes hydrolases that act on sugars (glycosylases)
- EC 3.3 includes hydrolases that act on ether bonds
- EC 3.4 includes hydrolases that act on peptide bonds (peptidases)
See also
References
EC 3 Introduction (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/intro.html) from the Department of Chemistry at Queen Mary University of Londonfr:Hydrolase pl:Hydrolaza