Oxidoreductase
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In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the oxidant, also called the hydrogen donor or electron donor) to another (the reductant, also called the hydrogen acceptor or electron acceptor). For example, an enzyme that catalyzed this reaction would be an oxidoreductase:
- A– + B → A + B–
In this example, A is the oxidant (electron donor) and B is the reductant (electron acceptor).
In biochemical reactions, the redox reactions are sometimes more difficult to see, such as this reaction from glycolysis:
- Pi + NAD+ + glyceraldehyde-3-phosphate → NADH + H+ + 1,3-bisphosphoglycerate
In this reaction, NAD+ is the reductant (hydrogen acceptor), and glyceraldehyde-3-phosphate is the oxidant (hydrogen donor).
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Nomenclature
Proper names of oxidoreductases are formed as "donor:acceptor oxidoreductase." However, common names are much more common. The common name is "donor dehydrogenase" when possible, such as glyceraldehyde-3-phosphate dehydrogenase for the second reaction above. Common names are also sometimes formed as "acceptor reductase," such as NAD+ reductase. "Donor oxidase" is a special case where O2 is the acceptor.
Classification
Oxidoreductases are classified as EC 1 in the EC number classification of enzymes. Oxidoreductases can be further classified into 22 subclasses:
- EC 1.1 includes oxidoreductases that act on the CH-OH group of donors
- EC 1.2 includes oxidoreductases that act on the aldehyde or oxo group of donors
- EC 1.3 includes oxidoreductases that act on the CH-CH group of donors
- EC 1.4 includes oxidoreductases that act on the CH-NH2 group of donors
- EC 1.5 includes oxidoreductases that act on CH-NH group of donors
- EC 1.6 includes oxidoreductases that act on NADH or NADPH
- EC 1.7 includes oxidoreductases that act on other nitrogenous compounds as donors
- EC 1.8 includes oxidoreductases that act on a sulfur group of donors
- EC 1.9 includes oxidoreductases that act on a heme group of donors
- EC 1.10 includes oxidoreductases that act on diphenols and related substances as donors
- EC 1.11 includes oxidoreductases that act on peroxide as an acceptor (peroxidases)
- EC 1.12 includes oxidoreductases that act on hydrogen as donors
- EC 1.13 includes oxidoreductases that act on single donors with incorporation of molecular oxygen (oxygenases)
- EC 1.14 includes oxidoreductases that act on paired donors with incorporation of molecular oxygen
- EC 1.15 includes oxidoreductases that act on superoxide radicals as acceptors
- EC 1.16 includes oxidoreductases that oxidize metal ions
- EC 1.17 includes oxidoreductases that act on CH or CH2 groups
- EC 1.18 includes oxidoreductases that act on iron-sulfur proteins as donors
- EC 1.19 includes oxidoreductases that act on reduced flavodoxin as a donor
- EC 1.20 includes oxidoreductases that act on phosphorus or arsenic in donors
- EC 1.21 includes oxidoreductases that act on X-H and Y-H to form an X-Y bond
- EC 1.97 includes other oxidoreductases
See also
References
EC 1 Introduction (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/intro.html) from the Department of Chemistry at Queen Mary University of Londonfr:oxydo-réductase pl:Oksydoreduktaza