William Pickering
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- William Pickering (April 2 1796 – 1854), British publisher and bookseller (biography: Keynes, Geoffrey Kt. William Pickering Publisher. New York: Burt Franklin, 1969) [1] (http://www.orgs.muohio.edu/anthologies/bijou/youngcd/pick.html)
- William Pickering (March 15 1798 – April 22 1873), Republican governor of Washington territory (1862 – 1866)
- William Henry Pickering (1858 – 1938), American astronomer
- William Hayward Pickering (1910 – 2004), director of the Jet Propulsion Laboratory
- William Pickering is the Director of the NRO in Dan Brown's book Deception Point.
- William Pickering was the first Protector appointed by the British administration of colonial Singapore to head the Chinese Protectorate.