U.S. Highway 38
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U.S. Highway 38 is the early, long-defunct (since 1932) designation of an east-west route connecting Omaha, Nebraska and Denver, Colorado. When U.S. Highway 6 was extended westward, the designation US 38 became obsolete and has never since been re-assigned to any other highway.
It had one "child" route, U.S. Highway 138, which was long the only "child" route without a "parent" before U.S. Highway 66 and U.S. Highway 99 were wholly decomissioned. US 138 remains in existence.