Histone methyltransferase
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Histone methyltransferases (HMT) are enzymes,histone-lysine N-methyltransferase and histone-arginine N-methyltransferase, which catalyze the transfer of one to three methyl groups from the cofactor s-adenosylmethionine to lysine and arginine residues of histone proteins. These proteins have been characterized by a SET (Su(var)3-9, Enhancer of Zeste, Trithorax) domain, however the recently discovered HMT Dot1 lacks the characteristic SET domain.