Estrone

Structural formula of estrone
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Structural formula of estrone

Estrone is an estrogenic hormone secreted by the ovary. Its empirical formula is C18H22O2. Estrone has a melting point of 254.5 Celsius.

Synthesis

Estrone is synthesized from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.

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Reaction-Androstendione-Estrone.png
Image:Reaction-Androstendione-Estrone.png

Template:Biochem-stubfr:Estrone

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