Acute phase protein
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Acute phase proteins are a class of proteins that are synthetized in the liver in response to inflammation. This response is called the acute phase reaction.
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Inflammatory cells and red blood cells
In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notably the interleukins IL-1, IL-6 and IL-11 and TNF-alpha.
The liver responds by producing a large number of acute phase reactants, most notably: