2C-T-21

2C-T-21 is a psychedelic phenethylamine first synthesized by Alexander Shulgin, sometimes used as an entheogen. The full name of the chemical is 4-(2-fluoroethylthio)-2,5-dimethoxyphenethylamine. In his book PIHKAL (Phenethylamines I Have Known and Loved), Shulgin lists the dosage range as 8 to 12 mg. 2C-T-21 is generally taken orally, and effects typically last 7 to 10 hours. The potential psychotherapeutic applications of this chemical were explored by Myron Stolaroff who found it a very promising substance in his experiments. 2C-T-21 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-21 could potentially be prosecuted under the Federal Analog Act because of its structural similarities to 2C-T-7. In the wake of Operation Web Tryp in July 2004, this will likely be going to court.

On March 9, 2004, a 22-year-old quadriplegic man named James Edwards Downs in St. Francisville, Louisiana, consumed an unknown dose of 2C-T-21 by sticking his tongue into a vial of powder he had purchased from www.americanchemicalsupply.com - a practice he had been engaging in since purchasing a gram. He developed temperature of 108 degrees Fahrenheit, had a grand mal seizure, and slipped into a coma. Four days later, on March 13, Downs died at Lane Memorial Hospital in Zachary, LA. This death became part of a two year DEA investigation called Operation Web Tryp which was launched in 2002 following the death of a New York man who had taken unspecified chemicals purchased from David Linder (aka Pondman or Dr. Benway, the latter a reference to a character created by author and drug addict William S. Burroughs). On July 22, 2004, the owners of American Chemical Supply were arrested on federal charges relating to distribution of controlled substance analogues and the death of James Edwards Downs.

Little is known about the toxicity of 2C-T-21 beyond this incident.

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