User talk:Techelf
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Hello Techelf, welcome to Wikipedia. Here's some tips:
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I hope you enjoy editing here and being a Wikipedian! Angela. 10:23, Apr 4, 2004 (UTC)
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ACE inhibitor
Congrats on your nice work on captopril and ACE inhibitor. I'm curious what your field is; you a pharmacologist/pharmacists by any chance? There's a WikiProject "Drugs", and I was wondering if you'd like to join & participate. JFW | T@lk 10:05, 27 Jun 2004 (UTC)
- Welcome to the WikiProject. Wikipedia could use some drug people (and as a doctor I know too little to write up all those nice pills we prescribe...) Yes, I should have looked at your user profile... JFW | T@lk 10:34, 27 Jun 2004 (UTC)
cytochrome p450
Thanks for the cleanup. Alteripse 12:43, 20 Sep 2004 (UTC)
Omeprazole structure
Hello,
your omeprazole structure formula seems to be not correct. You have there methoxydimethylphenyl group, which should be methoxydimethylpyridyl.. Could you please fix it? Regards, Mykhal 10:26, 4 Oct 2004 (UTC)
- You're right about the structure, and I've fixed it. Thanks for pointing that out. Incidentally, the LosecŪ Approved Product Information in Australia (sourced from E-MIMS) has the wrong structure; as that was what I based my sketch on (without checking). I've also fixed up the structure of esomeprazole. Techelf 14:29, 4 Oct 2004 (UTC)
Esomeprazole structure
Hi, I have recently noticed, that your esomeprazole structure has wrong stereochemistry. It is actually an R isomer, not S. Please fix it. Mykhal 21:54, 20 Oct 2004 (UTC)
- What I have drawn is, actually, the correct structure of S-omeprazole. The S designation of this molecule is with respect to its structure in vivo - where the sulfinyl moiety is ionised, and there is an additional hydrogen substituent off the chiral sulfur. Under these circumstances the stereochemistry is clearly S. So whilst, technically, this drawing may be R, it actually does represent the structure of S-omeprazole.
- Also, with regards to the "di" that I had accidentally placed in front of the structural formulae of omeprazole and esomeprazole, these were oversights when I was transposing the name from the proprietary preparation "di-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole magnesium trihydrate". I had overlooked the fact that the "di" referred to the whole molecule and forgot to remove it. But thanks for noticing that - one of those small details that I wouldn't otherwise have noticed.
- After all, I'm a pharmacy student, not a "chemist". =) Techelf 11:10, 21 Oct 2004 (UTC)
- I do not agree/understand your explanation. The drug is a chemical compound, the structure should be the one representing the substance present in the bottle. We know the structure of omeprazole. It is a chiral compound, it has asymmetric sulfur atom (sulfoxide). It can be R or S.. according to databases, esomeprazole has S configuration .. your of esomeprazole has R. Please correct me if I'm wrong somewhere :) Mykhal 21:54, 21 Oct 2004 (UTC)
- You might make mistake when copying the structure - you probably flipped the oxygen atom down but have forgotten to invert the stereo bond.. Mykhal 11:59, 22 Oct 2004 (UTC)
- I concede the point and have revised the drawing accordingly. I had initially (wrongly) supposed that the orientation of the substituents off the chiral sulfur was of a trigonal planar configuration; therefore I had assumed that the orientation of the oxygen substituent would not make a difference. In retrospect, I've realised that the sulfur substituents have a tetrahedral configuration; so you are right about the oxygen substituent being inverted - well spotted. Techelf 06:46, 23 Oct 2004 (UTC)
- I know, this is not obvious, that on the sulfur atom is lone electron pair which is the fourth "substituent" with lowest priority.. Thank you for the immediate action. Mykhal 08:54, 23 Oct 2004 (UTC)
Imatinib
What problem are you trying to solve by adding <br> tags to the long chemical name in the Imatinib article? I would have expected that just letting the browser break the long word would be sufficient. What browser did the wrong thing, and what did it do wrong? —AlanBarrett 18:24, 5 Nov 2004 (UTC)
- Hi Alan, the purpose of the <br> tags is mainly for Gecko-based browser (Mozilla, Firefox, Netscape, Camino, etc) which, for some reason, don't seem to break at hyphens in any of the longer IUPAC names I've entered into Wikipedia drug infoboxes; so the drugbox can sometimes become wider than the entire screen. Gecko-based browsers do break at spaces, though, which is why I had those spaces in the name - but the <br> solution probably looks more accurate to more people. It seems to work out okay this way for Internet Explorer, but it does look a bit strange in Safari - probably just needs a bit of tweaking with regards to where the linebreak is placed. I haven't had a chance to test it out in Opera yet unfortunately. Techelf 13:09, 6 Nov 2004 (UTC)
- I usually use Opera, and it breaks the line at hyphens. I just tried Firefox, and it does not break at hyphens. I suppose the explicit <br> tags are better than the bad browser behaviour. —AlanBarrett 15:53, 6 Nov 2004 (UTC)
Trimethoprim
Hi, Kieren. Could you take another look at your diagram in the article trimethoprim, please? I think that sulfonamides block dihydropteroate synthase, not reductase. Axl 16:05, 15 Nov 2004 (UTC)
- Yep, you're right. I've uploaded the fixed diagram. Techelf 06:15, 16 Nov 2004 (UTC)
- Er, the picture still says 'reductase' when I view it. By the way, would you like to add your name to the Wikipedia:WikiProject Clinical medicine page? Axl 10:29, 17 Nov 2004 (UTC)
Drug addiction vs drug dependence
Hi Techelf :) Sure, I believe that it is a very important distinction to make, especially with current medical situation of pain management. Patients are made to suffer unneccessarily while physicians fear prosecution, (or that their patients will become addicted). The vast majority of patients who come to use opioids have no problems stopping when the pain is healed (despite withdrawal symptoms), and why is there a concern of addiction for patients with chronic pain? If their pain is not going to go away, why worry that they will have problems ceasing use of opioids? I'd certainly like to hear your opinions on this subject. --Thoric 03:37, 6 Dec 2004 (UTC)
Article Licensing
Hi, I've started a drive to get users to multi-license all of their contributions that they've made to either (1) all U.S. state, county, and city articles or (2) all articles, using the Creative Commons Attribution-Share Alike (CC-by-sa) v1.0 and v2.0 Licenses or into the public domain if they prefer. The CC-by-sa license is a true free documentation license that is similar to Wikipedia's license, the GFDL, but it allows other projects, such as WikiTravel, to use our articles. Since you are among the top 2000 Wikipedians by edits, I was wondering if you would be willing to multi-license all of your contributions or at minimum those on the geographic articles. Over 90% of people asked have agreed. For More Information:
- Multi-Licensing FAQ - Lots of questions answered
- Multi-Licensing Guide
- Free the Rambot Articles Project
To allow us to track those users who muli-license their contributions, many users copy and paste the "{{DualLicenseWithCC-BySA-Dual}}" template into their user page, but there are other options at Template messages/User namespace. The following examples could also copied and pasted into your user page:
- Option 1
- I agree to [[Wikipedia:Multi-licensing|multi-license]] all my contributions, with the exception of my user pages, as described below:
- {{DualLicenseWithCC-BySA-Dual}}
OR
- Option 2
- I agree to [[Wikipedia:Multi-licensing|multi-license]] all my contributions to any [[U.S. state]], county, or city article as described below:
- {{DualLicenseWithCC-BySA-Dual}}
Or if you wanted to place your work into the public domain, you could replace "{{DualLicenseWithCC-BySA-Dual}}" with "{{MultiLicensePD}}". If you only prefer using the GFDL, I would like to know that too. Please let me know what you think at my talk page. It's important to know either way so no one keeps asking. -- Ram-Man (comment (http://en.wikipedia.org/w/wiki.phtml?title=User_talk:Ram-Man&action=edit§ion=new)| talk)
:-)
No worries, you deserve the barnstar :-) Ta bu shi da yu 11:57, 14 Dec 2004 (UTC)
Ibuprofen vs. aspirin
Kieren, I wonder if you have anything further to say about these questions from Dan100? Thanks. Axl 15:38, 21 Dec 2004 (UTC)
Diuretics
I just wanted to say that I agree wholeheartadly that Wikipedia needs some serious work on diuretics pages. I've been wanting to put some work into it for some time but somehow I never seem to have the time to get around to it.
Do you think it would be worth while to get some basic info up and then let people fill in the details or would it be better to do one page (thouroughly) at a time?
--Selket 05:59, 15 Mar 2005 (UTC)
Drug dependence
I saw your comments on Thoric's talk page, and I'm basically interested in the same issue. I would also like to get your opinion on the drug abuse article and where you think it should go. --Viriditas | Talk 22:57, 13 Apr 2005 (UTC)