Telempath
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Telempath (1983), by Spider Robinson, is a science fiction novel set in a dystopian near-future in which human cities have fallen into ruin and the population has been sharply reduced. It is a novel-length expansion of Robinson's Hugo award-winning novella "By Any Other Name".
The novel's protagonist, Isham Stone, is on a mission to kill the man allegedly responsible: a scientist named Wendell Carlson, currently living alone at the former Columbia University in what used to be New York City.
Isham has been told by his father, scientist Jacob Stone, that Carlson is a madman who brought the world to its current state by releasing a "hyperosmic plague": a virus that increases the sensitivity of the human sense of smell by many hundred times. With their senses of smell thus heightened, humans were unable to tolerate the odors produced by their own pollution-producing technology; the result was mass insanity and widespread rioting.
Another result was the discovery of a species of "Muskys" -- intelligent plasmoids -- that live in the Earth's upper atmosphere and feed on human pollutants. The curtailment of technological activity has caused them to approach the planet's surface and attack human beings, on whose fear they are apparently able to feed.
Isham sets out for New York and succeeds in locating Carlson. He learns from Carlson, however, that the man actually responsible for developing and releasing the plague is Isham's father Jacob. Isham returns to his home colony and sets a trap to kill his father, then returns to New York.
The original novella, "By Any Other Name", ends at this point. The novel continues as Isham's old teacher, Collaci, sets out to bring him back from New York to face a murder charge.
Isham is successfully captured, but before he can be tried, his colony is attacked by Agros (anti-technology worshippers of Pan) and he is taken prisoner.
Eventually Isham manages to bring about a measure of peace between the scientists and the neo-Luddites -- and also learns that his father is not dead. The newly reconciled factions of humanity set out to rebuild civilization.