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- For other uses, see Santo António (disambiguation).
Santo António is the main settlement of Príncipe island in São Tomé and Príncipe and was the then colony's capital from 1753 until 1852. It lies on the north east coast and the Palhota River. It serves as the capital of both Príncipe Province and the district of Pagué and has an estimated population of 1,200 residents.
The town is known for its colonial architecture and for its churches, the largest of which is the main Roman Catholic church, begun in 1947. The town is also known for the Auto da Floripes play.