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In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body.
- Primary iron overload (see the Haemochromatosis page):
- Type 1: Haemochromatosis associated to mutations in the HFE gene:
- C282Y homozygosity
- C282Y/H63D compound heterozygosity
- Type 2: Juvenile hereditary iron overload
- 2A: mutation of an unknown gene, tentatively called HFE2A
- 2B: mutation in hepcidin antimicrobial peptide (HAMP)
- Type 3: Hereditary iron overload associated to mutations in the Transferrin receptor 2 gene
- Type 4: Hereditary iron overload associated to mutations in the SLC11A3 gene (Ferroportin/MTP/IREG-1)
- Aceruloplasminaemia (rare disease)
- Congenital atransferrinaemia (rare disease)
- Others (unidentified genes)
- Juvenile haemochromatosis
- Neonatal haemochromatosis
- Secondary iron overload
- Miscellaneous
Sources
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