Genecyst
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Genecyst was a popular Sega Genesis/Sega Megadrive emulator for DOS, by Bloodlust Software (the same team that made NESticle). Until the release of Gens, it was widely regarded to be the best Genesis/Megadrive emulator with the nearest competitor being KGen.
Since Gens appeared with many features such as Sega CD emulation, as well as having a Microsoft Windows-based GUI, Genecyst has been left on the shelf. It is still remarkably fast on older CPUs, however.
The emulator is no longer updated.