Urease
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Urease-1E9Z.jpg
Urease-1E9Z.jpg
Urease (EC 3.5.1.5 (http://us.expasy.org/cgi-bin/nicezyme.pl?3.5.1.5)) is an enzyme that catalyzes the hydrolysis of urea into carbon dioxide and ammonia. The reaction occurs as follows: (NH2)2CO + H2O → CO2 + NH3
In 1926 James Sumner shows that urease is a protein. Urease is found in bacteria, yeast and several higher plants.
Characteristics:
- Molecular weight : 480 kDa
- Optimum pH : 7.4
- Enzymatic specificity: urea and hydroxyurea
- Inhibitors : heavy metals, sodium, potassium
A specific urease (which may be used in diagnosis) occurs in Helicobacter pylori.de:Urease