Myristicin

Template:NPOV Myristicin is a chemical present in nutmeg. It has hallucinogenic properties at doses much higher than used in cooking.

Myristicin is a naturally occurring insecticide and acaricide with probable neurotoxic effects on dopaminergic neurons. It causes brain damage.

There have been speculations in 1963 by Alexander Shulgin that myristicin could be converted to an amphetamine metabolite in the liver by transamination [1] (http://leda.lycaeum.org/?ID=16539). This could never never be verified and seems highly unlikely from what is known about the metabolism of the related compounds safrole to piperonylic acid.

Myristicin is a weak inhibitor of monoamine oxidase [2] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13994372).

Intoxications with myristicin or nutmeg essential oil do not resemble the effects of MDMA, MMDA, or of psychedelic drugs. (Myristicin can, however, be converted into MMDA using a similar reaction process to convert safrole into MDMA.) Effects vary from person to person, but are often reported to be a state somewhere between waking and dreaming; nausea is often experienced, but some report that using cannabis can offset the nausea (please see Erowid: Nutmeg (http://www.erowid.org/plants/nutmeg) for various primary and secondary sources related to nutmeg/myristicin intoxication).

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