Twenty Major League Baseball players have reached 500 home runs in their career:
| Player
| Team
| Date
| Opponent
| Pitcher
| Stadium
|
| Babe Ruth
| New York Yankees
| August 11, 1929
| Cleveland Indians
| Willis Hudlin
|
|
| Jimmie Foxx
| Boston Red Sox
| September 24, 1940
| Philadelphia Athletics
| George Caster
|
|
| Mel Ott
| New York Giants
| August 1, 1945
|
|
|
|
| Ted Williams
| Boston Red Sox
| June 17, 1960
| Cleveland Indians
|
|
|
| Willie Mays
| San Francisco Giants
| September 13, 1965
| Houston Astros
| Don Nottebart
|
|
| Mickey Mantle
| New York Yankees
| May 14, 1967
|
|
|
|
| Eddie Mathews
| Houston Astros
| July 14, 1967
| San Francisco Giants
| Juan Marichal
| Candlestick Park
|
| Hank Aaron
| Atlanta Braves
| July 14, 1968
| San Francisco Giants
| Mike McCormick
|
|
| Ernie Banks
| Chicago Cubs
| May 12, 1970
| Atlanta Braves
| Pat Jarvis
| Wrigley Field
|
| Harmon Killebrew
| Minnesota Twins
| August 10, 1971
| Baltimore Orioles
|
|
|
| Frank Robinson
| Baltimore Orioles
| September 13, 1971
| Detroit Tigers
|
|
|
| Willie McCovey
| San Francisco Giants
| June 30, 1978
| Atlanta Braves
| Jamie Easterley
| Atlanta-Fulton County Stadium
|
| Reggie Jackson
| California Angels
| September 17, 1984
| Kansas City Royals
| Bud Black
|
|
| Mike Schmidt
| Philadelphia Phillies
| April 18, 1987
| Pittsburgh Pirates
| Don Robinson
|
|
| Eddie Murray
| Baltimore Orioles
| September 6, 1996
| Detroit Tigers
| Felipe Lira
|
|
| Mark McGwire
| St. Louis Cardinals
| August 5, 1999
| San Diego Padres
| Andy Ashby
| Busch Stadium
|
| Barry Bonds
| San Francisco Giants
| April 17, 2001
| Los Angeles Dodgers
| Terry Adams
| Pacific Bell Park
|
| Sammy Sosa
| Chicago Cubs
| April 4, 2003
| Cincinnati Reds
| Scott Sullivan
| Great American Ball Park
|
| Rafael Palmeiro
| Texas Rangers
| May 11, 2003
| Cleveland Indians
| David Elder
| The Ballpark in Arlington
|
| Ken Griffey, Jr.
| Cincinnati Reds
| June 20, 2004
| St. Louis Cardinals
| Matt Morris
| Busch Stadium
|
Four players have reached 600 home runs in their career:
Three players have reached 700 home runs in their career:
