Hot 100 No. 1 Hits of 1981 (USA)
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These are the Billboard Hot 100 #1 Hits of 1981:
See also: 1981 in music, List of Number 1 Hits (USA)
| Issue Date | Song | Artist |
| January 31 | The Tide Is High | Blondie |
| February 7 | Celebration | Kool & The Gang |
| February 21 | 9 To 5 | Dolly Parton |
| February 28 | I Love A Rainy Night | Eddie Rabbitt |
| March 21 | Keep On Loving You | REO Speedwagon |
| March 28 | Rapture | Blondie |
| April 11 | Kiss On My List | Daryl Hall & John Oates |
| May 2 | Morning Train (Nine To Five) | Sheena Easton |
| May 16 | Bette Davis Eyes | Kim Carnes |
| June 20 | Medley | Stars on 45 |
| July 25 | The One That You Love | Air Supply |
| August 1 | Jessie's Girl | Rick Springfield |
| August 15 | Endless Love | Diana Ross & Lionel Richie |
| October 17 | Arthur's Theme (Best That You Can Do) | Christopher Cross |
| November 7 | Private Eyes | Daryl Hall & John Oates |
| November 21 | Physical | Olivia Newton-John |