FOXP2
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FOXP2 ("forkhead box P2") is a gene that is implicated in the development of language skills, including grammatical competence.
There are several reasons for believing that the linguistic impairments associated with a mutation of the FOXP2 gene are not simply the result of a fundamental deficit in motor control. For example:
- the impairments include difficulties in comprehension;
- brain imaging of affected individuals indicates functional abnormalities in language-related cortical regions, demonstrating that the problems extend beyond the motor system.
Although FOXP2 exists in many animals, the modern human form of FOXP2 appears to have evolved in Homo sapiens some time in the last 200,000 years. This has provided some support for speculation about a link between the evolution of the modern human form of FOXP2 with the advent of modern human creativity and culture.
See also
References
- Lai CSL, Fisher SE, Hurst JA, et al.: A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 2001, 413:519-523.
- Enard W, Przeworski M, Fisher SE, et al.: Molecular evolution of FOXP2, a gene involved in speech and language. Nature 2002, doi:10.1038/nature01025.
External links
- Protein Spotlight: The FOXP2 story (http://www.expasy.org/spotlight/back_issues/sptlt051.shtml)
- Molecular evolution of language: Biological selection for mutated FOXP2 (http://www.biomedcentral.com/news/20020815/02/) from biomedcentral
- 'Genetic changes' triggered Man's artistic abilities: FOXP2 (http://www.timesonline.co.uk/article/0,,3-580851,00.html)
- Scientific articles on FOXP2 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=FOXP2) in PubMed
- Molecular evolution of FOXP2, a gene involved in speech and language (http://www.zoology.ubc.ca/edg/pdf/FoxP.pdf) article published in Nature
- The FOXP2 gene in neurological development (http://www.well.ox.ac.uk/~simon/FOXP2/index.shtml)
- FOXP2 and the Evolution of Language (http://www.evolutionpages.com/FOXP2_language.htm)