- Cosmo is an abbreviated name for Cosmopolitan Magazine
- The Mazda Cosmo is a sports car
- The title character in Cosmo's Cosmic Adventure, a 1992 computer game series produced by Apogee Software
- Cosmo (The Fairly OddParents) is a cartoon character
- Cosmo is an abbreviation of "Cosmopolitan," an alcoholic drink made from vodka, cointreau or triple sec, lime juice, and cranberry juice.
- Cosmo Topper was the main character in "Topper" (http://www.geocities.com/TelevisionCity/4198/topperep.htm), an early 1950's sitcom about a staid banker, and the three ghosts which only he could see or hear, George and Marion Kerby, and a martini-drinking St. Bernard.
- Cosmo Kramer was the character played by Michael Richards in the NBC television sitcom Seinfeld.
- "Cosmo is a plant creature introduced in the 53rd episode of" "[Sonic X]".
