Brimstone
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- Brimstone, an ancient name for the element sulfur (or sulphur).
- Brimstone, a novel (2004) written by Douglas Preston and Lincoln Child.
- Brimstone, a short-lived television series.
- Brimstone, a butterfly species.
- Brimstone Moth
- Brimstone Hill Fortress National Park is a UNESCO World Heritage Site.
- The Brimstone missile is an advanced Anti-Tank Guided Missile (ATGM).
- Brimstone is a character that first appeared in the 1989 DC Comics miniseries, Legends.
- Brimstone and Treacle is a 1970s play by Dennis Potter.