Agnes Skinner
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In the TV series The Simpsons, Agnes Skinner is Seymour's mother, with whom he still lives. When Agnes makes an appearance, she is usually controlling some aspect of Seymour's life. Agnes owns a dress that is held up by the collective will of the room which she is in. She always yells "Seymour!" to Principal Skinner for something.
Mrs. Skinner dated Comic Book Guy in "Worst Episode Ever" [CABF08], in which a heart attack forces Comic Book Guy to take a break from running his store, The Android Dungeon — much to Principal Skinner's dismay.
Agnes means lamb. Lamb of God.
References
Simpson Crazy episode guide http://www.simpsoncrazy.com/episodeguide/season12/cabf08.shtml