The Deputy Secretary of State of the United States is the chief assistant to the Secretary of State who is responsible for foreign affairs. If the Secretary of State resigns or dies, the Deputy Secretary of State becomes Acting Secretary of State until the President and Senate appoint a replacement.
The position was created in 1972.
The current Deputy Secretary of State is Robert B. Zoellick, under Dr. Condoleezza Rice.
List of Deputy Secretaries of state:
| John N. Irwin II | New York | July 13, 1972 | February 1, 1973
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| Kenneth Rush | New York | February 2, 1973 | May 29, 1974
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| Robert S. Ingersoll | Illinois | July 10, 1974 | March 31, 1976
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| Charles W. Robinson | California | April 9, 1976 | January 20, 1977
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| Warren Christopher | California | February 26, 1977 | January 16, 1981
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| William P. Clark | California | February 25, 1981 | February 9, 1982
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| Walter John Stoessel Jr. | California | February 11, 1982 | September 22, 1982
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| Kenneth W. Dam | Illinois | September 23, 1982 | June 15, 1985
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| John C. Whitehead | New Jersey | July 9, 1985 | January 20, 1989
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| Lawrence Eagleburger | Florida | January 20 1989 | August 19, 1992
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| Clifton R. Wharton Jr. | New York | January 27, 1993 | November 8, 1993
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| Strobe Talbott | Ohio | February 23, 1994 | January 19, 2001
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| Richard Armitage | Virginia | March 26, 2001 | February 22, 2005
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| Robert Zoellick | Illinois | February 22, 2005 | Present
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