Tay syndrome
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Tay syndrome is a recessive hereditary disease characterised by trichothiodystrophy (sulfur-deficient brittle hair) with photosensitivity, ichthyosiform erythroderma, dystrophic (abnormal) finger and toe-nails, progeria-like facies (prematurely aged looking face), growth and mental retardation, infertility and variable other defects.
It is named after Dr. Tay Chong Hai, a Singaporean doctor who discovered and subsequently published a paper on it in 1971. Dr. Tay is the first doctor in South East Asia to be honoured by having a disease named after him. The Tay syndrome should not be confused with the Tay-Sachs disease.
Tay syndrome is synonymous with:
- IBIDS (ichthyosis-brittle hair-impaired intelligence-decreased fertility-short stature) syndrome
- congenital ichthyosis-trichodystrophy syndrome
- ichthyosiform erythroderma-hair abnormality-mental and growth retardation syndrome
- PIBI(D)S [photosensitivity-ichthyosis-brittle hair-impaired intelligence-(possibly decreased fertility)-short stature] syndrome
- sulfur-deficient brittle hair syndrome
- trichothiodystrophy 2 (TTD 2)
- trichothiodystrophy-congenital ichthyosis syndrome
- trichothiodystrophy-xeroderma pigmentosum syndrome
External references
NIH document on Tay syndrome (http://www.nlm.nih.gov/cgi/jablonski/syndrome_cgi?index=624)