Talk:Helicobacter pylori
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Honey treatment research
As for as I can tell, the external link to Honey Research Around the World (http://www.nhb.org/foodtech/rsrchref.html) leads to two relevant abstracts and this article: Causes of the antimicrobial activity of honey (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9505176).
One of the two abstracts seems never to have led to a full publication. The other seems to have been followed up by: Osmotic effect of honey on growth and viability of Helicobacter pylori (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10080135).
This is another reference for the action of honey on H. pylori: Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8308841).
It might be useful to have a section for research on non-antibiotic treatments for H. pylori. Unfortunately, this 2003 review (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12562687) indicates that no clinical trials for alternative therapies have shown positive results.
- Removed the external link on honey research as they are all 5-10 years old (1994-1999) and recent treatment guidelines do not mention them. The lastest link from Helicobacter journal Aug 2004 - The Year in Helicobacter pylori 2004 (http://www.helicobacter.org/content/publications/helicobacter_2004/2004.htm) in the chapter Therapy of Helicobacter pylori (http://www.blackwell-synergy.com/links/doi/10.1111/j.1083-4389.2004.00251.x/full/) under Novel agents does include this "Bee glue propolis, has antimicrobial and anti-inflammatory effects and in vitro studies have shown its effectiveness in inhibiting H. pylori." [1] (http://jmm.sgmjournals.org/cgi/content/abstract/52/5/417?view=abstract) Other novel agents are also listed in the journal article include ginger root and essential oils. Petersam 08:22, 22 Dec 2004 (UTC)
- Important distinction, most alternative treatments including honey and gum are all in-vitro, which falls short of even Marshall's one man experiment. GraemeLeggett 11:32, 18 Feb 2005 (UTC)
References
The above linked site offers a wealth of information that could really help to solidify this article and make it more accurate and reliable. It is to available text of the journal Helicobacter pylori and has potentially better information than the 1994 NIH study. Specifically one of the articles has actual risk factor statistics for the increase in gastric cancer due to H. pylori. I am unfortunately not in the position to understand the details of the subject, so hopefully someone that is can make use of the articles from the above link to improve the article and its citation. - Taxman 23:43, Dec 22, 2004 (UTC)
- As a side note, does anyone know about the prestige of the Helicobacter pylori journal or its peer review practices? - Taxman 23:43, Dec 22, 2004 (UTC)
I will do a Pubmed search and filter some useful references. The original discovery of the bug in the early 1980s will need to be refenced. As for the H. Pylori journal, this is a typical niche journal. The really relevant studies will have been published in the big core journals like The Lancet, NEJM, JAMA or the BMJ, or the core specialist journals (Am J Gastroenterol & Gut). JFW | T@lk 08:26, 23 Dec 2004 (UTC)
- Go to GUT (http://gut.bmjjournals.com/) for that Journal GraemeLeggett 11:02, 18 Feb 2005 (UTC)
Organisms in the stomach
I have changed the text to show that Heicobacter thrives in the stomach rather than survives. Many organisism suvive a transit of the stomach including many bacteria and protozoan spores, Cryptospoidium, Giardia etc, many viruses, some parasitic platyhelminths, flukes, tape-worms, prions etc.
I am also concerned about the authority for the statement that it "....can literally screw itself into the stomach lining." This implies some form of active burrowing activity which is not a characteristic of other helical bacteria. Is this referenced authoritatively somewhere ?
It is probably also incorrect to refer to 'poor' people at being at highest risk. The epidemiology shows that affluent young Caucasions in the English speaking world are least at risk , but that doesn't equate to rich and poor. It is more a reflection of local customs and habits with the low incidence group adopting life-styles based on high standards of cleanliness and hygiene. Other life-styles may provide different but equally worth-while benefits not enjoyed by young white Americans.
Velela 13:27, 2 Mar 2005 (UTC)
- Hp is a very active bacteria, those flagella do thrust it along. The stomach lining is question is the mucus layer rather than the flesh. GraemeLeggett 13:32, 2 Mar 2005 (UTC)
Weird ungrammaticality in "Infection and Diagnosis"
In er March 2nd edit, Velela deleted part of the sentence "Under poor sanitary conditions...", so that it is now ungrammatical; this change persisted subsequent edits. I about to edit it back, so that it is grammatical. I claim no knowledge of the subject material, and so hope that someone who is expert will audit this semi-reversion (semi- because this was not Velela's entire edit). --jholman 06:09, 26 Mar 2005 (UTC)
Microaerophilic
Does this term derive from aerophilism- an organism that can live in an enviroment that has extremly limited oxygen content? What is the format for adding in a term like this that doesn't quite deserve a full entry? Aerophilism doesn't exist in the Extremophile article, so one might add a new stub defining that. But what about microaerophilism- how could you make a stub of a stub? Would formating the article so that microaerophilic only has 'areophilic' linked?
- I suggest a link through to aerobic organism GraemeLeggett 14:15, 28 Mar 2005 (UTC)
taxobox
beautiful table