Zoe
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- Zoe, an æon of Gnostic belief systems, paired with Logos
- Zoe of Byzantium
- Zoe (Sesame Street)
- Zoe, a friend of Betty Spaghetty
- Zoe (band), a rock en español band from Mexico
- The videogame and anime series Zone of the Enders is commonly abbreviated as ZOE
- Zoe Herriot is a character in the long-running British science fiction television series Doctor Who.
- Zoe (robot) is a four wheeled robot that found life in the Atacama Desert.