GMC
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The initialism GMC can mean either:
- GMC, a division of General Motors formerly named "GMC Truck"
- General Medical Council (of the United Kingdom)
- Greater Manchester County
- Genetically Modified Crop
- Giant Molecular Cloud
- Global Motion Compensation used by video codecs
- Gebrüder Märklin & Cie, a German model railway manufacturer, see Märklin
- GNU Midnight Commander, a file manager for Unix-like systems
- Game Maker Community, a game making utility forum.