S-adenosyl-methionine
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S-adenosyl-methionine is the most important methyl donor in the body.
It is sometimes referred to as S-Adenosylmethionine or S-Adenosyl-L-Methionine.
In the United States it is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe; pronounced "sam ee"). This means it doesn't have to pass the FDA's tests required of drugs.
Some research[1] (http://www.ahcpr.gov/clinic/epcsums/samesum.htm) has shown that taking SAM-e on a regular basis can help fight depression, liver disease, and the pain of osteoarthritis.
External links
- S-Adenosyl Methionine as a food supplement: Pros and Cons (http://www.stoneclinic.com/sam_e.htm)
- S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial (http://www.biomedcentral.com/1471-2474/5/6)
- S-Adenosyl-Methionine in Depression: A Comprehensive Review of the Literature (http://www.biomedcentral.com/1523-3812/5/460/abstract) (Abstract only)
- Testimony before the House of Representatives Committee on Government Reform Hearing on Dietary Supplements. (HRG Publication #1560) (http://www.citizen.org/publications/release.cfm?ID=6763)
- About.com SAM-e Resource Index (http://arthritis.about.com/od/same/)