Reed-Sternberg cell
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Reed-Sternberg cells are abnormal cells found on light microscopy in biopsies from individuals with Hodgkin's disease (a type of lymphoma), and certain other disorders. They are derived from B lymphocytes.
They are named after Dorothy Reed (1874-1964) and either Carl von Sternberg or George M. Sternberg (1838-1915) - there is conflicting data on which is the correct Sternberg.
Reed-Sternberg cells are large and are either multinucleated or have a bilobed nucleus (thus resembling an "owl's eye" appearance) with prominent eosinophilic inclusion-like nucleoli. Reed-Sternberg cells are CD30 and CD15 positive. Although the presence of these cells is necessary for the diagnosis of Hodgkin's lymphoma (where the number of cells found in the lesion is directly proportional to the severity of the disease variants), cells are found in other disorders as well (such as infectious mononucleosis).