Proline
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L-Proline is one of the twenty amino acids (formerly, proline was misleadingly called an imino acid) that are used by living organisms as a building block of proteins (so called proteinogenic amino acids).
In proteins, proline can act as a structural disruptor for (α) helices, and as a turning point in β sheets. Multiple prolines in a row can create a proline helix. Sequences of proline and 1-Aminoisobutyric acid (Aib) form a helical turn structure.
Incorporated into peptides proline forms a tertiary amide. It does not have a hydrogen on the amide group and can therefore not act as a hydrogen bond donor.
Data :
- Chemical formula: NH8C5O2
- Abbreviation: Pro / P
- Molecular weight : 115.13
- Isoelectric point : 6.30
- van der Waals volume : 90
- pK1 (α-COOH): 1.95
- pK2 (αN-H): 10.64
- Protein Occurrence: 5.2%
- See also : biochemistryde:Prolin
es:Prolina eo:Prolino fr:Proline he:פרולין it:Prolina ja:プロリン nl:Proline pl:Prolina sv:Prolin