Pre-replication complex

A pre-replication complex is a protein complex that forms at the origin of replication during the initiation step of DNA replication.

The following factors make up the complex:

  • A helicase, which unwinds the DNA ahead of the fork (dnaA).
  • A primase, which generates an RNA primer to be used in DNA replication (dnaG).
  • A DNA holoenzyme, which is actually a complex of enzymes that performs the actual replication.

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