Phosphoglucomutase
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Phosphoglucomutase-1JDY.jpg
Phosphoglucomutase-1JDY.jpg
Rabbit muscle phosphoglucomutase
Phosphoglucomutase (EC 5.4.2.2 (http://www.expasy.org/cgi-bin/nicezyme.pl?5.4.2.2);) is an enzyme that creates a glucose isomer by changing the site of the phosphate ion.
After glycogen phosphorylase has broken off a single glucose molecule from the greater glycogen structure, the free glucose has a phosphate group on its 1-carbon. This glucose-1-phosphate isomer cannot be metabolized easily. The enzyme phosphoglucomutase phosphorylates the 6-carbon, while subsequently dephosphorylating the 1-carbon. The result is glucose-6-phosphate, which can now theoretically travel down the glycolysis or pentose phosphate pathway.