Guts
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- In medicine or physiology, guts is a slang term for the gastrointestinal tract
- In most English-speaking countries, "guts" is a slang term meaning courage or fortitude
- In sports, Guts is a team sport involving a flying disc.
- GUTs: acronym for Grand Unified Theories
- Guts (book) is a management book by Robert A. Lutz, former CEO of Chrysler
- Guts is a short story by Chuck Palahniuk that appears in his book Haunted
- "Guts" is also the name of a poker variant.
- GUTS was a 30-minute sports game show which aired on Nickelodeon from 1992 to 1995.
- Guts is the main character of the anime and manga called Berserk.