Guanylate cyclase
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Guanylate cyclase (EC 4.6.1.2 (http://www.expasy.org/cgi-bin/get-enzyme-entry?4.6.1.2), also known as guanylyl cyclase or GC) is a lyase, an enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. There are soluble and membrane-bound forms of guanylyl cyclases. Soluble GC (sGC) is activated by nitric oxide, most notably involved in vasodilation. Membrane-bound forms are receptors: GC-A & GC-B for natriuretic factors such as Atrial Natriuretic Factor, and GC-C for Guanylin.