Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus
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Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus, (An Anatomical Exercise on the Motion of the Heart and Blood in Animals) is physician William Harvey's most well-known work. The book was published in 1628.
He investigated the effect of ligatures on blood flow. The book also argued that blood was pumped around the body in a "double circulation", where after being returned to the heart, it is recirculated in a closed system to the lungs and back to the heart, where it is returned to the main circulation.