Emma Eckstein
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Emma Eckstein (1865 - 1924) was an early patient of Sigmund Freud who underwent disastrous nasal surgery, undertaken by Freud's friend and confidant, Wilhelm Fleiss. She came from a prominent socialist family and was active in the Viennese women's movement. When she was 27, she came to Freud seeking treatment for vague symptoms including stomach ailments and slight depression related to menstruation. Freud diagnosed Eckstein as suffering from trauma, secondary to childhood sexual abuse. Freud suspected, in addition, a "nasal reflex neurosis," a condition popularized by Fliess, an ear, nose and throat specialist. Fliess had been treating the nasal reflex neurosis in his own patients with local anesthesia, specifically cocaine, and found that the treatment yielded positive results, in that his patients became less depressed. Fliess conjectured that if temporary cauterization was temporarily useful, perhaps surgery would yield more permanant results. He began operating on the noses of patients he diagnosed with the disorder, including Eckstein and even Freud himself.
Eckstein's surgery was a disaster. She suffered from terrible infections for some time, and profuse bleeding. Freud called in a specialist who removed a mass of surgical gauze that Fleiss had not removed. Eckstein's nasal passages were so damaged that she was left permanently disfigured. Freud initially attributed this damage to the surgery, but later, as an attempt to reassure his friend that he shouldn't blame himself, attributed the continued symptoms to hysteria.
Text of letter from Freud to Fliess on the aftermath of Emma Eckstein's surgery (http://www.haverford.edu/psych/ddavis/f_emma.html)