Elephantiasis

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Elephantiasis is a parasitic disease which is transmitted from human to human by mosquito bites. The parasite tends to lodge in and block the lymph nodes that drain into the lower extremities, producing massive enlargement and deformity of the legs and genitalia. Dramatic photographs of those affected appear in every infectious disease text.

Organisms that cause the disease are Wuchereria bancrofti, Brugia malayi, and B. timori, all transmitted by mosquitoes. Lymphatic filariasis currently affects 120 million people worldwide, and 40 million of these people have serious disease. The disease is also called bancrofitan filariasis and lymphatic filariasis. Brugia malayi causes a similar disease, while Onchocerca volvulus causes many disorders including elephantiasis.

Medicines to treat lymphatic filariasis are most effective when used soon after infection, but they do have some toxic side effects. In addition, the disease is difficult to detect early. Therefore, improved treatments and laboratory tests are needed. A vaccine is not yet available.

References

National Institutes of Health, USA (http://www2.niaid.nih.gov/newsroom/focuson/bugborne01/filar.htm)Template:Med-stub de:Elefantiasis

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