- A down is a hill, usually made of chalk and in southern England. See downland.
- Down is the negative direction along the z-axis. Up and down are the only two well-defined directions in the presence of gravity. Earlier this was adown, meaning "from the hill".
- Down syndrome is a genetic disorder.
- County Down is a county in Northern Ireland.
- Down is a district in Northern Ireland.
- Downe is a village in Kent, where Charles Darwin's house, Down House, is.
- Down feathers are the fine undercoat of birds under the visible exterior feathers, and is often used as insulation in clothing.
- Down hair is another term for the undercoat of some mammals.
- Down is a common command in dog training.
- Down, used in American football, is a stage of play; four downs are allowed in a "possession"; three downs are allowed in Canadian football. The reference is to the ball or ball carrier being brought to a halt, often by being knocked down.
- Down is a colloquial synonym for depressed or blue.
- A computer (or other) system can go down when it essentially loses power or crashes.
- Down is a heavy metal band.
- Down is a song by blink-182. The song's video, made in 2004, features many former gang members as part of an agency that talks people out of gangs and into the entertainment industry.
- Downing or whacking off is to finish a drink (typically a pint of beer) in one go without pause for breath. This usually takes place during drinking games, or at least circumstances where they might be played. Respect is earned by finishing the drink suitably quickly; failing to do so at all may result in ridicule.
