Double-blind
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Double-blind describes an especially stringent way of conducting an experiment, usually on human subjects, in such as way as to attempt to eliminate subjective bias on the part of both experimental subjects and the experimenters.
In a single-blind experiment, the individual subjects do not know whether they are so-called "test" subjects or members of an "experimental control" group. In such a trial there is a risk that subjects are influenced by interaction with the researchers - known as the experimenter effect.
In a double-blind experiment, neither the individuals nor the researchers know who belongs to the control group. Only after all the data are recorded (and in some cases, analyzed) may researchers be permitted to learn which individuals are which. Performing an experiment in double-blind fashion is a way to lessen the influence of prejudices and unintentional physical cues on the results.
Strictly speaking, every researcher who interacts with or treats a subject should be "blinded", if an experiment is to be designated "double-blind." This situation is easily arranged when the treatment being tested is a drug, the appearance of which may be simulated with a colored pill or solution (that is, a placebo). But with surgical procedures, for example, a surgeon inevitably knows whether it is the procedure or a sham that he or she is performing. The evaluation of such procedures can be approximately double-blind if the researchers responsible for recording subjects' responses and analyzing the data are blinded. Such a test typically is not considered "double-blind."
See also
External links
- http://naturalscience.com/ns/articles/01-15/ns_leavitt.html This shows why the double blind, though valuable, is limited.
- ICH Website (http://www.ich.org)
- FDA Website (http://www.fda.gov/)
- Clinical Research Training (http://www.kriger.com/training/index.htm)
- Careers in Clinical Research (http://www.biorole.com/)
- Clinical Research Services (http://www.clinqua.com/)
- Clinical Research Companies Listings (http://www.ibpassociation.com)
- International Clinical Research Services and Corporate Trainings (http://www.kriger.com/)
- Clinical Research Abbreviations and Acronyms (http://www.krctraining.com/ACRONYMS/index.htm)
- Clinical Research Glossary / Definitions (http://www.krctraining.com/CRA%20Definitions/index.htm)
- List of Food and Drugs Regulatory Agencies (http://www.kriger.com/international_modules/index.htm)
- Clinical Research: Frequently asked questions (http://www.krctraining.com/faq/faq.htm)fr:Étude randomisée en double aveugle