- In Roman mythology, Dīs was an alternate name for Pluto, god of the underworld and darkness. Its name comes from a shortening of dīves ("wealthy", from the belief that the wealth from the ground came from the underworld), which in turn derived from the Proto-Indo-European root *dyeu (which is also the source of other deity names such as Jupiter, Diana, Zeus, Dione, Tiu, Tyr, Devi and Asmodai).
- In Celtic mythology, Dis was the Roman name assigned to the supreme god of the Celts by Julius Caesar.
- In Dante's The Divine Comedy, Dis was both the name of the city separating the fifth and sixth circles of Hell and an alternate name for Lucifer.
- In keeping with this general theme, Dis is also the name of the virtual machine within the Inferno computer operating system. Dis was designed to execute programs written in the programming language Limbo.
- Dis is also an interpreted programming language, derivated from Malbolge. Those two languages were designed to be as hard to use as possible, but still Turing-complete.
- Dis is also an Ebonics slang word for "disrespect".
- Dís is also a fictional character from J. R. R. Tolkien's Middle-earth
- In the Dungeons and Dragons roleplaying game, Dis is the name of the second layer of the hellish plane Baator.
