Beta-lactamase
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Beta-lactamase is a type of enzyme responsible for bacterial resistance to beta-lactam antibiotics. Among these are penicillins, cephalosporins, carbapenems and others. They have a common element in their molecular structure, a four-atom ring known as a beta-lactam. The lactamase enzyme breaks that ring open, deactivating the molecule's antibiotic properties.
The structure of a Streptomyces β lactamase is given by PDB 1BSG (http://www.rcsb.org/pdb/cgi/explore.cgi?pid=149261034357864&page=0&pdbId=1BSG) EC 3.5.2.6)
See also:
Reference
- Jacoby GA, Munoz-Price LS. The new β-lactamases. N Engl J Med 2005;352:380-91. PMID 15673804fr:Bêta-lactamase