Stimulation
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Stimulation is the irritating action of various agents (stimuli) on muscles, nerves, or a sensory end organ, by which activity is evoked; especially, the nervous impulse produced by various agents on nerves, or a sensory end organ, by which the part connected with the nerve is thrown into a state of activity.
The word is also often used metaphorically. For example, an interesting or fun activity can be described as "stimulating," regardless of its physical effects on nerves.