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Melatonin

From Academic Kids

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Melatonin.png
Chemical structure of melatonin.


Melatonin
5-methoxy-N-acetyltryptamine
Empiric formula C13H16N2O2
Molecular weight 232.28
Bioavailability 30 - 50%
Metabolism Liver
Elimination half life 32 - 40 minutes
Excretion Urine
Pregnancy category ?
Delivery

1mg, 2.5mg, 3mg, and 5mg capsules;
1mg/mL or 1mg/4mL liquid;
.5mg and 3mg lozenges;
2.5mg sublingual tablets;
1mg, 2mg, and 3mg timed-release tablets

Indicated for:

Melatonin, or 5-methoxy-N-acetyltryptamine, is a hormone produced by pinealocytes in the pineal gland, located in the brain, but also in the retina and GI tract. It is a derivative of the amino acid tryptophan.

Melatonin produced in the pineal gland acts as an endocrine hormone since it is released into the blood. On the other hand, melatonin produced by the retina and the GI tract is considered a paracrine hormone.

Melatonin helps regulate sleep-wake or circadian rhythms. Normally, production of melatonin by the pineal gland is stimulated by darkness and inhibited by light. Melatonin can suppress libido by inhibiting secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary gland -- especially in mammals that have a breeding season when daylight hours are long, such as sheep. Nobel Prize laureate Julius Axelrod performed many of the seminal experiments elucidating the role of melatonin and the pineal gland in circadian rhythms. Beta blockers decrease nocturnal melatonin release.

Melatonin is synthesized by various plants such as rice and ingested melatonin was shown to be capable of reaching and binding to melatonin binding sites in the brain of mammals [1] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7773197&dopt=Abstract).

In recent times, melatonin has become available as a drug and a dietary supplement. It appears to have some use against insomnia and jet lag. Melatonin is a powerful antioxidant which can easily cross cell membranes. It has been studied for the treatment of cancer, immune disorders, cardiovascular diseases, depression, seasonal affective disorder, and sexual dysfunction; no apparent benefit in these has been found.

To synthesize melatonin, serotonin is converted to N-acetylserotonin by the enzyme 5-HT N-acetyltransferase. N-acetylserotonin is then converted to melatonin by the enzyme 5-hydroxyindole-O-methyltransferase. See serotonin for details on how tryptophan is converted to serotonin.

Melatonin has been shown to increase the lifespan of mice by 20% in some studies [2] (http://www.ceri.com/melaton.htm) [3] (http://www.cris.com/~nubrain/melatonin.html) [4] (http://www.lef.org/magazine/mag95/95dec3.htm) [5] (http://www.demogr.mpg.de/general/structure/division1/lab-asm/118.htm).

Safety

Note: Wikipedia does not give medical advice.

  • Use of melatonin by persons who already have an abundant supply of melatonin from their bodies, such as children, teenagers, and pregnant and lactating women can lead to overdose of melatonin.
  • Melatonin taken with MAOI drugs can also lead to overdose because MAOIs inhibit the breakdown of melatonin by the body.

External links

Template:Tryptaminesde:Melatonin es:Melatonina fr:Mlatonine he:מלטונין nl:Melatonine ja:メラトニン pl:Melatonina sv:Melatonin

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