Hydrochlorothiazide

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Hydrochlorothiazide.png
Hydrochlorothiazide chemical structure


Hydrochlorothiazide

6-chloro-3,4-dihydro-2H-
1,2,4-benzothiadiazine-
7-sulfonamide 1,1-dioxide
CAS number
58-93-5
ATC code
C03AA03
Chemical formula C7H8ClN3O4S2
Molecular weight 297.742
Bioavailability  ?
Metabolism  ?
Elimination half-life  ?
Excretion  ?
Pregnancy category  ?
Legal status  ?
Routes of administration Oral

Hydrochlorothiazide (HCZ or HCT) is a popular diuretic drug that acts by inhibiting the kidney's ability to retain water.

Activity

Hydrochlorothiazide belongs to the thiazide class of diuretics, acting on the kidney to reduce sodium (Na) reabsorption in the distal convoluted tubule. This reduces the osmotic pressure in the kidney, causing less water to be reabsorbed by the collecting ducts.

Indications

It is often used to treat hypertension, congestive heart failure and symptomatic edema. It is effective in diabetes insipidus and is also sometimes used in hypercalciuria.

Hypokalemia, an occasional side-effect, can be usually prevented by potassium supplements or combining hydrochlorothiazide with a potassium-sparing diuretic.

Side effects

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